Our first key technology is nucleic acid organic chemistry, which uses the power of chemistry to “make” DNA as desired. Phosphoramidite chemistry enables sequential coupling of ATGC nucleotides in completely chemical process. Our advantage is that we can freely tune the process to suit our own preferences.
By utilizing our knowledge of organic chemistry, which is taught in the classes, moreover, we can create reagents for writing yet unknown “characters” other than ATGC. While making full use of a wide variety of commercially available reagents, we have been creating molecular devices and machines with functions beyond those of nature by writing these unnatural “characters” into DNA using automatic DNA synthesizers. A typical example is the development of “molecular machine fluorescent probes,” which combine a fluorescent dye and a quencher through a mechanical coupling and operate with an unprecedented mechanism.
→Creating a diagnostic agent
The fact that we can freely synthesize DNA is a major advantage that differentiates us from other research groups competing on the world stage.
→Creating DDS carriers
→Creating artificial antibodies
→Creating molecular robots
→Creating artificial muscles
→Producing artificial organs
→Go to “Programming DNA“
→Back to “Research Topics“