Publications

<Original Papers>

100. DNA Origami-Based Luminescent Biosensors Enabling Smartphone Detection of Nucleic Acid Sequences
Shuhei Kido,* Nozomu Takahashi, Hiroshi Miyazaki, Sachiko Kono, Keita Saito, Akinori Kuzuya*
ACS Omega 2025, 10 (37), 43300–43308.
99. Nonequilibrium Self‐Assembly of Microtubules Through Stepwise Sequential Interactions of DNA
Jakia Jannat Keya, Mousumi Akter, Yuta Yamasaki, Yoshiyuki Kageyama, Kazuki Sada, Akinori Kuzuya,* Akira Kakugo*
Small 2025, 21 (26), 2408364.
98. DNA Origami-Constructed Nanotapes for Sunitinib Adsorption and Inhibition of Renal Clear Carcinoma Cells
Lin Li, Xuxiang Yao, Pengyao Wei, Dongdong He, Qiaojiao Ding, Bing Bai, Xiuyi Lv, Akinori Kuzuya, Yuling Wang, Kerong Wu,* Kaizhe Wang,* Jianping Zheng*
ACS Omega 2024, 9 (31), 33765–33772.
97. Sustained-Release of Antigens and CpG-DNA using Temperature-Responsive Biodegradable Injectable Polymers: Performance on Induction of Immune Responses
Yuta Yoshizaki,* Kenta Horii, Nobuo Murase, Akinori Kuzuya, and Yuichi Ohya*
Adv. Ther. 2024, 7 (8), 2300296.
96. Gelation upon the Mixing of Amphiphilic Graft and Triblock Copolymers Containing Enantiomeric Polylactide Segments through Stereocomplex Formation
Yuichi Ohya*, Yasuyuki Yoshida, Taiki Kumagae, and Akinori Kuzuya
Gels 2024, 10 (2), 139.
95. Synthesis of Topological Gels by Penetrating Polymerization Using a Molecular Net
Yuichi Ohya*, Ryota Dohi, Fumika Seko, Yuto Nakazawa, Ken-ichiro Mizuguchi, Kosei Shinzaki, Takahiko Yasui, Hiroaki Ogawa, Shizuka Kato, Yuta Yoshizaki, Nobuo Murase, and Akinori Kuzuya
Angew. Chem. Int. Ed. 2024, 63 (11), e202317045.
94. Development of immune cell delivery system using biodegradable injectable polymers for cancer immunotherapy
Yuta Yoshizaki,* Kenta Horii, Nobuo Murase, Akinori Kuzuya, and Yuichi Ohya*
Int. J. Pharm. 2024, 652, 123801.
93. Drug Delivery with Hyaluronic Acid-Coated Polymeric Micelles in Liver Fibrosis Therapy
Yuta Yoshizaki, Manami Yamasaki, Takuya Nagata, Kengo Suzuki, Rio Yamada, Takuma Kato, Nobuo Murase, Akinori Kuzuya, Akira Asai, Kazuhide Higuchi, Kosuke Kaji, Hitoshi Yoshiji, and Yuichi Ohya*
ACS Biomater. Sci. Eng. 2023, 9 (6), 3414–3424.
92. A systematic study on the effects of the structure of block copolymers of PEG and poly(ε-caprolactone-co-glycolic acid) on their temperature-responsive sol-to-gel transition behavior
Yuichi Ohya,* Hidenori Yonezawa, Chiro Moriwaki, Nobuo Murase, and Akinori Kuzuya
Polym. Chem. 2023, 14 (12), 1350–1358.
91. Loss of multipotency in adipose-derived stem cells after culture in temperature-responsive injectable polymer hydrogels
Nozomi Mayumi, Nobuo Murase, Yuta Yoshizaki, Akinori Kuzuya, and Yuichi Ohya*
Polym. J. 2023, 55 (3), 261–271.
90. Synthesis of degradable double network gels using a hydrolysable cross-linker
Takanori Yokoi, Akinori Kuzuya, Tasuku Nakajima, Takayuki Kurokawa, Jian Ping Gong, and Yuichi Ohya*
Polym. Chem. 2022, 13 (25), 3756–3762.
89. Cooperative cargo transportation by a swarm of molecular machines
Mousumi Akter, Jakia Jannat Keya, Kentaro Kayano, Arif Md. Rashedul Kabir, Daisuke Inoue, Henry Hess, Kazuki Sada, Akinori Kuzuya, Hiroyuki Asanuma, and Akira Kakugo*
Science Robot. 2022, 7 (65), eabm0677.
88. Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery
Keigo Suzuki, Yuta Yoshizaki, Kenta Horii, Nobuo Murase, Akinori Kuzuya, and Yuichi Ohya*
Biomater. Sci. 2022, 10 (8), 1920–1928.
87. Reactive-Oxygen-Species-Mediated Surface Oxidation of Single-Molecule DNA Origami by an Atomic Force Microscope Tip-Mounted C60 Photocatalyst
Ankita Ray, Cristiana Passiu, Masayuki Nasuda, Shivaprakash N. Ramakrishna, Antonella Rossi, Akinori Kuzuya, Nicholas D. Spencer, and Yoko Yamakoshi*
ACS Nano 2021, 15 (12), 19256–19265.
86. Temperature-Responsive Biodegradable Injectable Polymers with Tissue Adhesive Properties
Soichiro Fujiwara, Yuta Yoshizaki, Akinori Kuzuya, and Yuichi Ohya*
Acta Biomaterialia 2021, 135, 318-330.
85. Cellular therapy for myocardial ischemia using a temperature-responsive biodegradable injectable polymer system with adipose-derived stem cells
Yuta Yoshizaki, Hiroki Takai, Nozomi Mayumi, Soichiro Fujiwara, Akinori Kuzuya, and Yuichi Ohya*
Sci. Technol. Adv. Mater. 2021, 22 (1), 627-642.
84. Postoperative Adhesion Prevention Using a Biodegradable Temperature-Responsive Injectable Polymer System and Concomitant Effects of the Chymase Inhibitor
Yuta Yoshizaki, Takuya Nagata, Soichiro Fujiwara, Shinji Takai, Denan Jin, Akinori Kuzuya, and Yuichi Ohya*
ACS Appl. Bio Mater. 2021, 4 (4), 3079-3088.
83. Modeling a Microtubule Filaments Mesh Structure from Confocal Microscopy Imaging
Yutaka Ueno,* Kento Matsuda, Kaoru Katoh, Akinori Kuzuya, Akira Kakugo, and Akihiko Konagaya
Micromachines 2020, 11 (9), 844.
82. An intermolecular-split G-quadruplex DNAzyme sensor for dengue virus detection
Jeunice Ida, Akinori Kuzuya, Yee Siew Choong, and Theam Soon Lim*
RSC Adv. 2020, 10 (55), 33040-33051.
81. Single-molecule AFM study of DNA damage by 1O2 generated from photoexcited C60
Ankita Ray, Korinne Liosi, Shivaprakash N. Ramakrishna, Nicholas D. Spencer, Akinori Kuzuya,* and Yoko Yamakoshi*
J. Phys. Chem. Lett. 2020, 11 (18), 7819-7826.
80. Versatile cell-specific ligand arrangement system onto desired compartments of biodegradable matrices for site-selective cell adhesion using DNA tags
Hiromichi Sumida, Yuta Yoshizaki, Akinori Kuzuya, and Yuichi Ohya*
Biomacromolecules, 2020, 21 (9), 3713-3723.
79. Reversible Changes in the Orientation of Gold Nanorod Arrays on Polymer Brushes
Yu Sekizawa, Hideyuki Mitomo,* Mizuki Nihei, Satoshi Nakamura, Yusuke Yonamine, Akinori Kuzuya, Takehiko Wada, and Kuniharu Ijiro*
Nanoscale Adv. 2020, 2 (9), 3798-3803.
78. Sustained Drug-Releasing Systems Using Temperature-Responsive Injectable Polymers Containing Liposomes
Yuta Yoshizaki, Hiroki Yamamoto, Akinori Kuzuya, and Yuichi Ohya*
ACS Symp. Ser. 2020, 1350, 35-45.
77. Cellular Attachment Behavior on Biodegradable Polymer Surface Immobilizing Endothelial Cell-Specific Peptide
Yuichi Ohya,* Kazuki Nishimura, Hiromichi Sumida, Yuta Yoshizaki, Akinori Kuzuya, Atsushi Mahara, and Tetsuji Yamaoka*
J. Biomater. Sci., Polym. Ed., 2020, 31 (11), 1475-1488.
76. Thermal properties and degradation of enantiomeric copolyesteramides poly(lactic acid-co-alanine)s
Hideto Tsuji,* Shotaro Sato, Noriaki Masaki, Yuki Arakawa, Yuta Yoshizaki, Akinori Kuzuya, and Yuichi Ohya*
Polym. Degrad. Stab. 2020, 171, 109047.
75. Stereocomplex crystallization, homocrystallization, and polymorphism of enantiomeric copolyesteramides poly(lactic acid‐co‐alanine)s from the melt
Hideto Tsuji,* Shotaro Sato, Noriaki Masaki, Yuki Arakawa, Yuta Yoshizaki, Akinori Kuzuya, and Yuichi Ohya*
Polym. Crystallization 2020, 3 (2), e10094.
74. Artificial Smooth Muscle Model Composed of Hierarchically Ordered Microtubule Asters Mediated by DNA Origami Nanostructures
Kento Matsuda, Arif Md. Rashedul Kabir, Naohide Akamatsu, Ai Saito, Shumpei Ishikawa, Tsuyoshi Matsuyama, Oliver Ditzer, Md. Sirajul Islam, Yuichi Ohya, Kazuki Sada, Akihiko Konagaya, Akinori Kuzuya,* and Akira Kakugo*
Nano Lett. 2019, 19 (6), 3933-3938.
Featured on 日刊工業新聞, 日経産業新聞
73. Application of DNA Quadruplex Hydrogels Prepared from Polyethylene Glycol-Oligodeoxynucleotide Conjugates to Cell Culture Media
Shizuma Tanaka, Shinsuke Yukami, Yuhei Hachiro, Yuichi Ohya,* and Akinori Kuzuya*
Polymers 2019, 11 (10), 1607.
72. DNA Quadruplex Hydrogel Beads Showing Peroxidase Activity
Shizuma Tanaka, Soo Khim Chan, Theam Soon Lim, Yuichi Ohya, and Akinori Kuzuya*
J. Electrochem. Soc. 2019, 166 (9), B3271-B3273.
71. DNA Switch: Toehold-Mediated DNA Isothermal Amplification for Dengue Serotyping
Soo Khim Chan, Akinori Kuzuya, Yee Siew Choong, and Theam Soon Lim*
SLAS Discov., 2019, 24 (1), 68–76.
70. Bulk pH Responsive DNA Quadruplex Hydrogels Prepared by Liquid-Phase, Large-Scale DNA Synthesis
Shizuma Tanaka, Shinsuke Yukami, Kazuki Fukushima, Kenta Wakabayashi, Yuichi Ohya,* and Akinori Kuzuya*
ACS Macro Lett. 2018, 7 (3), 295-299.
69. DNA-assisted swarm control in a biomolecular motor system
Jakia Jannat Keya, Ryuhei Suzuki, Arif Md. Rashedul Kabir, Daisuke Inoue, Hiroyuki Asanuma, Kazuki Sada, Henry Hess, Akinori Kuzuya,* and Akira Kakugo*
Nature Commun. 2018, 9, 453.
Featured on 日刊工業新聞, 日経産業新聞, Chemistry World
68. Control of swarming of molecular robots
Jakia Jannat Keya, Arif Md. Rashedul Kabir, Daisuke Inoue, Kazuki Sada, Henry Hess, Akinori Kuzuya,* and Akira Kakugo*
Sci. Rep. 2018, 8, 11756.
67. Synthesis, stereocomplex crystallization and homo-crystallization of enantiomeric poly(lactic acid-co-alanine)s with ester and amide linkages
Hideto Tsuji,* Shotaro Sato, Noriaki Masaki, Yuki Arakawa, Akinori Kuzuya, and Yuichi Ohya*
Polym. Chem., 2018, 9 (5), 565-575.
66. Preparation of Biodegradable Oligo(lactide)s-Grafted Dextran Nanogels for Efficient Drug Delivery by Controlling Intracellular Traffic
Yuichi Ohya,* Akihiro Takahashi, and Akinori Kuzuya
Int. J. Mol. Sci., 2018, 16 (6), 1606.
65. Intelligent, biodegradable, and self-healing hydrogels utilizing DNA quadruplexes
Shizuma Tanaka, Kenta Wakabayashi, Kazuki Fukushima, Shinsuke Yukami, Ryuki Maezawa, Yuhei Takeda, Kohei Tatsumi, Yuichi Ohya,* and Akinori Kuzuya*
Chem. Asian J. 2017, 12 (18), 2388-2392.
64. Allosteric Control of Nanomechanical DNA Origami Pinching Devices for Enhanced Target Binding
Akinori Kuzuya,* Yusuke Sakai, Takahiro Yamazaki, Yan Xu, Yusei Yamanaka, Yuichi Ohya, and Makoto Komiyama*
Chem. Commun. 2017, 53 (59), 8276-8279.
63. Site-Selective RNA Activation by Acridine-Modified Oligodeoxynucleotides: A Comprehensive Study
Akinori Kuzuya,* Yun Shi, Keita Tanaka, Kenzo Machida, and Makoto Komiyama*
ACS Omega 2017, 2 (9), 5370-5377.
62. “DNA origami traffic lights” with split aptamer sensor for bicolor fluorescence readout
Heidi-Kristin Walter, Jens Bauer, Jeannine Steinmeyer, Akinori Kuzuya, Christof M. Niemeyer, and Hans-Achim Wagenknecht*
Nano Lett. 2017, 17 (4), 2467-2472.
61. Peptide drug release behavior from biodegradable temperature-responsive injectable hydrogels exhibiting irreversible gelation
Kazuyuki Takata, Hiroki Takai, Yuta Yoshizaki, Takuya Nagata, Keisuke Kawahara, Yasuyuki Yoshida, Akinori Kuzuya, and Yuichi Ohya*
Gels 2017, 3 (4), 38.
60. Analysis of the sol-to-gel transition behavior of temperature-responsive injectable polymer systems by fluorescence resonance energy transfer
Kazuyuki Takata, Keisuke Kawahara, Yasuyuki Yoshida, Akinori Kuzuya, and Yuichi Ohya*
Polym. J. 2017, 49 (9), 677-684.
59. Extemporaneously preparative biodegradable injectable polymer systems exhibiting temperature-responsive irreversible gelation
Yasuyuki Yoshida, Kazuyuki Takata, Hiroki Takai, Keisuke Kawahara, Akinori Kuzuya, and Yuichi Ohya*
J. Biomat. Sci. Polym. Ed. 2017, 28 (14), 1427-1443.
58. Injectable and biodegradable temperature-responsive mixed polymer systems providing variable gel-forming pH regions
Yasuyuki Yoshida, Keisuke Kawahara, Akinori Kuzuya, and Yuichi Ohya*
J. Biomat. Sci. Polym. Ed. 2017, 28 (10-12), 1158-1171.
57. Biodegradable injectable polymer systems exhibiting longer and controllable duration time of the gel state
Yasuyuki Yoshida, Hiroki Takai, Keisuke Kawahara, Kazuyuki Takata, Shintaro Mitsumune, Akinori Kuzuya, and Yuichi Ohya*
Biomater. Sci. 2017, 5 (7), 1304-1314.
56. Biodegradable Injectable Polymer Systems Exhibiting Temperature-Responsive Irreversible Sol-to-Gel Transition by Covalent Bond Formation
Yasuyuki Yoshida, Keisuke Kawahara, Kenta Inamoto, Shintaro Mitsumune, Shinya Ichikawa, Akinori Kuzuya, and Yuichi Ohya*
ACS Biomater. Sci. Eng. 2017, 3 (1), 56-67.
55. Synthesis and Temperature-responsiveness of Poly(ethylene glycol)-like Biodegradable Poly(ether-ester)s
Yuichi Ohya,* Akihiro Takahashi, Hiroki Takaishi, Akinori Kuzuya
ACS Symp. Ser. 2017, 1253, 93-104.
54. A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly
Maia Godonoga, Ting-Yu Lin, Azusa Oshima, Koji Sumitomo, Marco S. L. Tang, Yee-Wai Cheung, Andrew B. Kinghorn, Roderick M. Dirkzwager, Cunshan Zhou, Akinori Kuzuya, Julian A. Tanner, and Jonathan G. Heddle*
Sci. Rep. 2016, 6, 21266.
53. Stereocomplex- and homo-crystallization of blends from 2-armed poly(l-lactide) and poly(d-lactide) with identical and opposite chain directional architectures and of 2-armed stereo diblock poly(lactide)
Hideto Tsuji,* Kentaro Tamai, Takayuki Kimura, Akiyo Kubota, Akihiro Takahashi, Akinori Kuzuya, Yuichi Ohya*
Polymer 2016, 96, 167-181.
52. Crosslinked duplex DNA nanogels that target specified proteins
Yasuhiko Iwasaki,* Jun-ichi Kondo, Akinori Kuzuya, Rui Moriyama
Sci. Tech. Adv. Mater. 2016, 17 (1), 285-292.
51. Automatic Recognition of DNA Pliers in Atomic Force Microscopy Images
Yuexing Han,* Akito Hara, Akinori Kuzuya, Ryosuke Watanabe, Yuichi Ohya, and Akihiko Konagaya
New Gener. Comput. 2015, 33 (3), 253-270.
50. Encapsulation of a Gold Nanoparticle in a DNA Origami Container
Akinori Kuzuya,* Masafumi Kaino, Mirai Hashizume, Kazuki Matsumoto, Takeaki Uehara, Yasutaka Matsuo, Hideyuki Mitomo, Kenichi Niikura, Kuniharu Ijiro, and Yuichi Ohya*
Polym. J. 2015, 47 (2), 177-182.
49. Orthogonal Enzyme Arrays on a DNA Origami Scaffold Bearing Size-Tunable Wells
Takahiro Yamazaki, Jonathan Gardiner Heddle, Akinori Kuzuya,* and Makoto Komiyama*
Nanoscale 2014, 6 (15), 9122-9126.
48. Nanomechanical DNA Origami pH Sensors
Akinori Kuzuya,* Ryosuke Watanabe, Yusei Yamanaka, Takuya Tamaki, Masafumi Kaino, and Yuichi Ohya*
Sensors 2014, 14 (10), 19329-19335.
47. Precise Structure Control of Three-State Nanomechanical DNA Origami Devices
Akinori Kuzuya,* Ryosuke Watanabe, Mirai Hashizume, Masafumi Kaino, Shinya Minamida, Koji Kameda, and Yuichi Ohya*
Methods 2014, 67 (2), 250-255.
46. Instant preparation of a biodegradable injectable polymer formulation exhibiting a temperature-responsive sol-gel transition
Yasuyuki Yoshida, Akihiro Takahashi, Akinori Kuzuya, Yuichi Ohya*
Polym. J. 2014, 46 (9), 632-635.
45. A Macromolecular Prodrug-type Injectable Polymer Composed of Poly(depsipeptide-co-lactide)-g-PEG for Sustained Release of Drugs
Akihiro Takahashi, Masaya Umezaki, Yasuyuki Yoshida, Akinori Kuzuya, Yuichi Ohya*
Polym. Adv. Technol. 2014, 25 (11), 1226-1233.
44. Impact of Core-Forming Segment Structure on Drug Loading in Biodegradable Polymeric Micelles Using PEG-b-Poly(lactide-co-depsipeptide) Block Copolymers
Akihiro Takahashi, Yuta Ozaki, Akinori Kuzuya, Yuichi Ohya*
Biomed Res. Int. 2014, 579212.
43. The Effects of Molecular Structure on Sol-to-gel Transition of Biodegradable Poly(depsipeptide-co-lactide)-g-PEG Copolymers
Akihiro Takahashi, Masaya Umezaki, Yasuyuki Yoshida, Akinori Kuzuya, and Yuichi Ohya*
J. Biomat. Sci. Polym. Ed. 2014, 25 (5), 444-454.
42. Design of Biodegradable Injectable Polymers Exhibiting Temperature-Responsive Sol-Gel Transition
Yuichi Ohya, Hiroyuki Suzuki, Koji Nagahama, Akihiro Takahashi, Tatsuro Ouchi, Akinori Kuzuya
Adv. Sci. Technol. 2013, 86, 9-16.
41. Clear-Cut Observation of PNA Invasion Using Nanomechanical DNA Origami Devices
Takahiro Yamazaki, Yuichiro Aiba, Kohei Yasuda, Yusuke Sakai, Yusei Yamanaka, Akinori Kuzuya,* Yuichi Ohya, and Makoto Komiyama*
Chem. Commun. 2012, 48 (92), 11361-11363.
40. Enzyme Treatment-Free and Ligation-Independent Cloning Using Caged Primers in Polymerase Chain Reactions
Akinori Kuzuya,* Keita Tanaka, Hitoshi Katada, Makoto Komiyama*
Molecules 2012, 17 (1), 328-340.
39. Formation of 1D and 2D Gold Nanoparticle Arrays by Divalent DNA-Gold Nanoparticle Conjugates
Yuichi Ohya,* Nozomi Miyoshi, Mirai Hashizume, Takuya Tamaki, Takeaki Uehara, Shoso Shingubara, Akinori Kuzuya
Small 2012, 8 (15), 2335-2340.
38. Nanomechanical DNA Origami ‘Single-Molecule Beacons’ Directly Imaged by Atomic Force Microscopy
Akinori Kuzuya,* Yusuke Sakai, Takahiro Yamazaki, Yan Xu, and Makoto Komiyama*
Nature Commun. 2011, 2, 449.
Featured on Kakenhi NEWS Letter
37. Photo-Switching of Site-Selective RNA Scission by Sequential Incorporation of Azobenzene and Acridine Residues in a DNA Oligomer
Akinori Kuzuya, Keita Tanaka, Makoto Komiyama*
J. Nucleic Acids 2011, 2011, 162452.
36. Programmed Nanopatterning of Organic/Inorganic Nanoparticles Using Nanometer-Scale Wells Embedded in a DNA Origami Scaffold
Akinori Kuzuya,* Naohiro Koshi, Mayumi Kimura, Kentaro Numajiri, Takahiro Yamazaki, Toshiyuki Ohnishi, Fuminori Okada, Makoto Komiyama*
Small 2010, 6 (23), 2664-2667.
35. Discrete and Active Enzyme Nanoarrays on DNA Origami Scaffolds Purified by Affinity Tag Separation
Kentaro Numajiri, Takahiro Yamazaki, Mayumi Kimura, Akinori Kuzuya,* Makoto Komiyama*
J. Am. Chem. Soc. 2010, 132 (29), 9937-9939.
34. Stepwise and Reversible Nanopatterning of Proteins on a DNA Origami Scaffold
Kentaro Numajiri, Mayumi Kimura, Akinori Kuzuya,* Makoto Komiyama*
Chem. Commun. 2010, 46 (28), 5127-5129.
33. Blunt-Ended DNA Stacking Interactions in a 3-Helix Motif
Risheng Wang, Akinori Kuzuya, Wenyan Liu, and Nadrian C. Seeman*
Chem. Commun. 2010, 46 (27), 4905-4907.
32. Asymmetric Secondary and Tertiary Streptavidin/DNA Complexes Selectively Formed in a Nanometer-Scale DNA Well
Kentaro Numajiri, Akinori Kuzuya,* Makoto Komiyama*
Bioconjugate Chem. 2010, 21 (2), 338-344.
31. Dethreading of Deoxyribonucleotides through α-Cyclodextrin
Akinori Kuzuya,* Toshiyuki Ohnishi, Takahiro Yamazaki, Makoto Komiyama*
Chem. Asian J. 2010, 5 (10), 2177-2180.
30. Precisely Programmed and Robust 2D Streptavidin Nanoarrays by Using Periodical Nanometer-Scale Wells Embedded in DNA Origami Assembly
Akinori Kuzuya,* Mayumi Kimura, Kentaro Numajiri, Naohiro Koshi, Toshiyuki Ohnishi, Fuminori Okada, Makoto Komiyama*
ChemBioChem 2009, 10 (11), 1811-1815.
29. Efficient Guest Inclusion by β-Cyclodextrin Attached to the Ends of DNA Oligomers upon Hybridization to Various DNA Conjugates
Akinori Kuzuya,* Toshiyuki Ohnishi, Tsugutoshi Wasano, Suguru Nagaoka, Jun Sumaoka, Toshihiro Ihara,* Akinori Jyo, Makoto Komiyama*
Bioconjugate Chem. 2009, 20 (8), 1643-1649.
28. Precise Site-Selective Termination of DNA Replication by Caging The 3-Position of Thymidine and Its Application to Polymerase Chain Reaction
Akinori Kuzuya,* Fuminori Okada, Makoto Komiyama*
Bioconjugate Chem. 2009, 20 (10), 1924-1929.
27. Design and Construction of a Box-Shaped 3D-DNA Origami
Akinori Kuzuya,* and Makoto Komiyama*
Chem. Commun. 2009 (28), 4182-4184.
Selected as a Hot Article, and featured on Highlights in Chemical Science
26. Efficient Site-selective RNA Activation and Scission Achieved by Geometry Control of Acridine Intercalation in RNA/DNA Heteroduplex
Akinori Kuzuya, Yun Shi, Keita Tanaka, Kenzo Machida, Makoto Komiyama*
Chem. Lett. 2009, 38 (5), 432-433.
25. DNA/α-Cyclodextrin-Rotaxane Conjugate as a New Supramolecular Material
Akinori Kuzuya,* Toshiyuki Ohnishi, Makoto Komiyama*
Chem. Lett. 2008, 37 (9), 996-997.
24. Synthesis of Photo-Responsive Acridine-Modified DNA and Its Application to Site-Selective RNA Scission
Keita Tanaka, Yoji Yamamoto, Akinori Kuzuya, and Makoto Komiyama*
Nucleosides, Nucleotides Nucleic Acids 2008, 27 (10-11), 1175-1185.
23. Site-Selective Blocking of PCR by a Caged Nucleotide Leading to Direct Creation of Desired Sticky Ends in The Products
Keita Tanaka, Hitoshi Katada, Narumi Shigi, Akinori Kuzuya,* and Makoto Komiyama*
ChemBioChem 2008, 9 (13), 2120-2126.
22. Site-Selective Termination of DNA Replication by Using a Caged Template
Keita Tanaka, Akinori Kuzuya,* and Makoto Komiyama*
Chem. Lett. 2008, 37 (6), 584-585.
21. Accommodation of a Single Protein Guest in Nanometer-Scale Wells Embedded in a “DNA Nanotape”
Akinori Kuzuya, Kentaro Numajiri, and Makoto Komiyama*
Angew. Chem., Int. Ed. 2008, 47 (18), 3400-3402.
20. Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini
Yu Liu, Akinori Kuzuya, Ruojie Sha, Johan Guillaume, Risheng Wang, James W. Canary,* and Nadrian C. Seeman*
J. Am. Chem. Soc. 2008, 130 (33), 10882-10883.
19. Six-Helix and Eight-Helix DNA Nanotubes Assembled from Half-Tubes
Akinori Kuzuya, Risheng Wang, Ruojie Sha, and Nadrian C. Seeman*
Nano Lett. 2007, 7 (6), 1757-1763.
18. Simultaneous Genotyping of Indels and SNPs by Mass Spectroscopy
Takuro Sasayama, Mayu Kato, Hiroyuki Aburatani, Akinori Kuzuya, and Makoto Komiyama*
J. Am. Soc. Mass Spectrom. 2006, 17 (1), 3-8.
17. Lanthanide Ions as Versatile Catalyst in Biochemistry: Efficient Site-selective Scission of RNA by Free Lanthanide Ions
Akinori Kuzuya, Kenzo Machida, Takuro Sasayama, Yun Shi, Ryo Mizoguchi, and Makoto Komiyama*
J. Alloy. Compd. 2006, 408-412, 396-399.
16. Design of Phosphoramidite Monomer for Optimal Incorporation of Functional Intercalator to Main Chain of Oligonucleotide
Yun Shi, Kenzo Machida, Akinori Kuzuya, and Makoto Komiyama*
Bioconjugate Chem. 2005, 16 (2), 306-311.
15. Cooperation of Metal-Ion Fixation and Target-Site Activation for Efficient Site-Selective RNA Scission
Akinori Kuzuya, Yun Shi, Takuro Sasayama, and Makoto Komiyama*
J. Biol. Inorg. Chem. 2005, 10 (3), 270-274.
14. Selective Activation of Two Sites in RNA by Acridine-bearing Oligonucleotides for Clipping of Designated RNA Fragment
Akinori Kuzuya, Ryo Mizoguchi, Takuro Sasayama, J.-M. Zhou, and Makoto Komiyama*
J. Am. Chem. Soc. 2004, 126 (5), 1430-1436.
13. Crucial Role of Linker Portion in Acridine-Bearing Oligonucleotides for Highly Efficient Site-Selective RNA Scission
Yun Shi, Akinori Kuzuya, Kenzo Machida, and Makoto Komiyama*
Tetrahedron Lett. 2004, 45 (19), 3703-3706.
12. Non-Covalent Combination of Oligoamine and Oligonucleotide As Totally Organic Site-Selective RNA Cutter
Yun Shi, Fumiya Niikura, Akinori Kuzuya, and Makoto Komiyama*
Chem. Lett. 2004, 33 (8), 1012-1013.
11. Site-Selective RNA Scission at Two Sites for Precise Genotyping of SNPs by Mass Spectrometry
Akinori Kuzuya, Ryo Mizoguchi, Fumi Morisawa, and Makoto Komiyama*
Chem. Commun. 2003 (6), 770-771.
10. Stereochemically Pure Acridine-Modified DNA for Site-Selective Activation and Scission of RNA
Yun Shi, Akinori Kuzuya, and Makoto Komiyama*
Chem. Lett. 2003, 32 (5), 464-465.
9. Conjugation of Various Acridines to DNA for Site-Selective RNA Scission by Lanthanide Ion
Akinori Kuzuya, Kenzo Machida, Ryo Mizoguchi, and Makoto Komiyama*
Bioconjugate Chem. 2002, 13 (2), 365-369.
8. Metal Ion-Induced Site-Selective RNA Hydrolysis by Use of Acridine-Bearing Oligonucleotide as Cofactor
Akinori Kuzuya, Ryo Mizoguchi, Fumi Morisawa, Kenzo Machida, and Makoto Komiyama*
J. Am. Chem. Soc. 2002, 124 (24), 6887-6894.
7. A Highly Acidic Acridine for Efficient Site-Selective Activation of RNA Leading to an Eminent Ribozyme Mimic
Akinori Kuzuya, Kenzo Machida, and Makoto Komiyama*
Tetrahedron Lett. 2002, 43 (46), 8249-8252.
6. New Ribozyme-Mimics Employing Mg(II) Ion as Catalytic Center
Akinori Kuzuya, Ryo Mizoguchi, and Makoto Komiyama*
Chem. Lett. 2001, 30 (6), 584-585.
5. Non-Covalent Ternary Systems (DNA-Acridine Hybrid / DNA / Lanthanide(III)) for Efficient and Site-Selective RNA Scission
Akinori Kuzuya, and Makoto Komiyama*
Chem. Commun. 2000 (20), 2019-2020.
4. Sequence-Selective RNA Scission by Non-Covalent Combination of Acridine-Tethered DNA and Lanthanide(III) Ion
Akinori Kuzuya, and Makoto Komiyama*
Chem. Lett. 2000, 29 (12), 1378-1379.
3. Non-Covalent Combinations of Lanthanide(III) Ion and Two DNA Oligomers for Sequence-Selective RNA Scission
Akinori Kuzuya, Masahiro Akai, and Makoto Komiyama*
Chem. Lett. 1999, 28 (10), 1035-1036.
2. Conjugates of a Dinuclear Zinc(II) Complex and DNA Oligomers as Novel Sequence-Selective Artificial Ribonucleases
Shigeo Matsuda, Akira Ishikubo, Akinori Kuzuya, Morio Yashiro, and Makoto Komiyama*
Angew. Chem., Int. Ed. 1998, 37 (23), 3284-3286.
1. Molecular Design for a Pinpoint RNA Scission. Interposition of Oligoamines between Two DNA Oligomers
Masayuki Endo, Yasushi Azuma, Yoshiyuki Saga, Akinori Kuzuya, Gota Kawai, and Makoto Komiyama*
J. Org. Chem. 1997, 62 (4), 846-852.

<Proceedings>

13. AUTOMATIC RECOGNITION OF DNA NANOSTRUCTURES IN ATOMIC FORCE MICROSCOPY (AFM) IMAGE: FIRST EXPERIENCE ON DNA PLIERS
Yuexing Han, Akito Hara, Akinori Kuzuya, Ryousuke Watanae, Yuichi Ohya, and Akihiko Konagaya
International Conference on Applied and Theoretical Information Systems Research (ATISR2013) 2013.
12. Nanomechanical DNA Origami Devices as Versatile Molecular Sensors
Akinori Kuzuya,* Takahiro Yamazaki, Kohei Yasuda, Yusuke Sakai, Yusei Yamanaka, Yan Xu, Yuichiro Aiba, Yuichi Ohya, and Makoto Komiyama
IEEE NEMS 2012 2012, 405-408.
11. Restriction Enzyme Treatment/Ligation Independent Cloning Using Caged Primers for PCR
Akinori Kuzuya,* Keita Tanaka, Hitoshi Katada, Makoto Komiyama*
Nucleic Acids Symp. Ser. 2009, 53, 75-76.
19. Direct Preparation of Sticky-Ended Duplexes within PCR by Using Caged Primers
Keita Tanaka, Hitoshi Katada, Narumi Shigi, Akinori Kuzuya,* and Makoto Komiyama*
Nucleic Acids Symp. Ser. 2008, 52, 467-468.
9. Single-Molecule Accommodation of Streptavidin in Nanometer-Scale Wells Formed in DNA Nanostructures
Akinori Kuzuya,* Kentaro Numajiri, Mayumi Kimura, and Makoto Komiyama*
Nucleic Acids Symp. Ser. 2008, 52, 681-682.
8. A Robust DNA Framework for Single Molecule Observation with Atomic Force Microscope
Akinori Kuzuya, and Makoto Komiyama*
Nucleic Acids Symp. Ser. 2007, 51, 331-332.
7. Photocontrol of Site-Selective RNA Scission
Keita Tanaka, Yoji Yamamoto, Akinori Kuzuya, and Makoto Komiyama*
Nucleic Acids Symp. Ser. 2007, 51, 205-206.
6. Site-Selective RNA Scission by PNA-Lu(III) Hybrid System
Yoji Yamamoto, Mayumi Kimura, Mayu Kato, Akinori Kuzuya, and Makoto Komiyama*
Nucleic Acids Symp. Ser. 2006, 50, 267-268.
5. Simultaneous Use of Highly Acidic Acridine and Rigid Chiral Linker for Efficient Site-Selective RNA Scission
Yun Shi, Kenzo Machida, Akinori Kuzuya, and Makoto Komiyama*
Nucleic Acids Symp. Ser. 2004, 48, 219-220.
4. Tandem Site-Selective RNA Scission Utilizing Acridine-DNA Conjugates
Akinori Kuzuya, Ryo Mizoguchi, Takuro Sasayama, and Makoto Komiyama*
Nucleic Acids Res. Supple. 2003, 3, 167-168.
3. Novel Approach for SNP Genotyping Based of Site-Selective RNA Scission
Akinori Kuzuya, Ryo Mizoguchi, Fumi Morisawa, and Makoto Komiyama*
Nucleic Acids Res. Supple. 2002, 2, 129-130.
2. Site-Selective Artificial Ribonuclease Using Pinpoint RNA Activation
Akinori Kuzuya, Ryo Mizoguchi, and Makoto Komiyama*
Nucleic Acids Res. Supple. 2001, 1, 131-132.
1. Sequence-Selective RNA Scission by Oligoamine-DNA Conjugates
Akinori Kuzuya, Yasushi Azuma, Takuya Inokawa, Koichi Yoshinari, and Makoto Komiyama*
Nucleic Acids Symp. Ser. 1997, 37, 209-210.

<Reviews>

13. Molecular Origami: Designing Functional Molecules of the Future
Hitoshi Ishida,* Takeshi Ito, Akinori Kuzuya
Molecules 2025, 30 (2), 242.
12. From Molecular Robotics to Molecular Cybernetics: The First Step Toward Chemical Artificial Intelligence
Akinori Kuzuya,* Shin-Ichiro M. Nomura, Taro Toyota, Takashi Nakakuki, Satoshi Murata
IEEE Trans. Mol. Biol. Multi-Scale Commun. 2023, 9 (3), 354-363.
11. Supramolecular Enzyme-mimicking Catalysts Self-assembled from Peptides
Qing Liu,* Akinori Kuzuya, Zhen-Gang Wang*
iScience 2022, 26 (1), 105831.
10. Molecular Cybernetics: Challenges toward Cellular Chemical AI
Satoshi Murata,* Taro Toyota, Shin-ichiro M. Nomura, Takashi Nakakuki, Akinori Kuzuya
Adv. Funct. Mater. 2022, 32 (37), 2201866.
9. Molecular Swarm Robot Realized by the Intelligence of a Biomolecular Motor System and DNA
Jakia Jannat Keya, Akinori Kuzuya, and Akira Kakugo
Seibutsu Butsuri 2021, 61 (5), 330-331.
8. Hydrogels Utilizing G-Quadruplexes
Akinori Kuzuya,* and Shizuma Tanaka
MOJ Poly. Sci. 2017, 1 (6), 00033.
7. Nanomechanical Molecular Devices Made of DNA Origami
Akinori Kuzuya,* and Yuichi Ohya*
Acc. Chem. Res. 2014, 47 (6), 1742-1749.
6. DNA Nanostructures as Scaffolds for Metal Nanoparticles
Akinori Kuzuya,* and Yuichi Ohya*
Polymer J. 2012, 44 (6), 452-460.
5. DNA Origami: Fold, Stick, and Beyond
Akinori Kuzuya,* and Makoto Komiyama*
Nanoscale 2010, 2 (3), 310-322.
4. Non-covalent Site-selective Artificial Ribonucleases and Their Applications
Akinori Kuzuya, and Makoto Komiyama*
Curr. Org. Chem. 2007, 11 (16), 1450-1459.
3. DNA, PNA, and Their Derivatives for Precise Genotyping of SNPs
Akinori Kuzuya, J.-M. Zhou, and Makoto Komiyama*
Mini Rev. Org. Chem. 2004, 1 (1), 125-131.
2. Site-Selective Activation of RNA Leading to Sequence-Selective RNA Cutters
Makoto Komiyama,* Akinori Kuzuya, and Ryo Mizoguchi
Bull. Chem. Soc. Jpn. 2002, 75 (12), 2547-2554.
1. Sequence-Selective Artificial Ribonucleases
Makoto Komiyama,* Jun Sumaoka, Akinori Kuzuya, and Yoji Yamamoto
Methods Enzymol. 2001, 341, 455-468.

<Book Chapters>

5. 11 Books in Japanese
4. Molecular Material for Molecular Robots
Akinori Kuzuya
in Molecular Robotics, An Introduction, Satoshi Murata, Ed., pp 215-245, 2022, Springer, Singapore.
3. DNA Origami for Molecular Robotics
Akinori Kuzuya
in DNA Origami: Structures, Technology, and Applications, Masayuki Endo, Ed., pp 297-304, 2022, Wiley-VCH, Weinheim.
2. Manipulation of Molecular Architecture with DNA
Akinori Kuzuya
in Molecular Technology: Life Innovation, Hisashi Yamamoto & Takashi Kato, Ed., pp 25-42, 2018, Wiley-VCH, Weinheim.
1. Sequence Selective Artificial Ribonucleases Employing Metal Ions as Scissors
Akinori Kuzuya, Ryo Mizoguchi, and Makoto Komiyama*
in Artificial Ribonucleases, Marina. A. Zenkova, Ed., Nucleic Acids and Molecular Biology 13, pp 173-188, 2004, Springer-Verlag GmbH, Berlin.