{"id":3504,"date":"2025-12-05T15:43:37","date_gmt":"2025-12-05T06:43:37","guid":{"rendered":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/?p=3504"},"modified":"2025-12-07T09:18:41","modified_gmt":"2025-12-07T00:18:41","slug":"2025%e5%b9%b412%e6%9c%885%e6%97%a5ldi-ms-%e3%81%ab%e3%82%88%e3%82%8b%e9%87%91%e3%83%8a%e3%83%8e%e3%83%ad%e3%83%83%e3%83%89%e8%a1%a8%e9%9d%a2%e3%83%aa%e3%82%ac%e3%83%b3%e3%83%89%e4%ba%a4%e6%8f%9b","status":"publish","type":"post","link":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/2025\/12\/3504","title":{"rendered":"2025\u5e7412\u67085\u65e5[LDI-MS \u306b\u3088\u308b\u91d1\u30ca\u30ce\u30ed\u30c3\u30c9\u8868\u9762\u30ea\u30ac\u30f3\u30c9\u4ea4\u63db\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0] Mass Spectrometry\u8a8c\uff08\u65e5\u672c\u8cea\u91cf\u5206\u6790\u5b66\u4f1a\uff09\u306b\u8ad6\u6587\u30a2\u30af\u30bb\u30d7\u30c8"},"content":{"rendered":"\n

H.  Kawasaki*, Y.   Iwasaki, R.  Arakawa
Stepwise Monitoring of Ligand Exchange on Gold Nanorods: From Cetyltrimethylammonium Bromide to Thiol-Functionalized Biocompatible Phosphorylcholine Using Matrix-Free LDI-TOF Mass Spectrometry<\/a>
Mass spectrometry<\/strong><\/em>(2025). https:\/\/doi.org\/10.5702\/massspectrometry.A0184<\/p>\n\n\n\n

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  1. <\/li>\n<\/ol>\n\n\n\n

    \u91d1\u30ca\u30ce\u30ed\u30c3\u30c9\uff08AuNRs\uff09\u306f\u591a\u7528\u9014\u306b\u5c55\u958b\u3067\u304d\u308b\u6709\u671b\u306a\u30ca\u30ce\u6750\u6599\u3067\u3059\u304c\u3001\u8868\u9762\u3092\u8986\u3046 CTAB \u304c\u5f37\u56fa\u306b\u6b8b\u7559\u3059\u308b\u305f\u3081\u3001\u76ee\u7684\u306e\u30ea\u30ac\u30f3\u30c9\u3078\u7f6e\u63db\u3059\u308b\u969b\u306e\u5927\u304d\u306a\u969c\u58c1\u3068\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002
    \u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30d5\u30ea\u30fc LDI-TOF-MS \u3092\u7528\u3044\u3066\u3001AuNR \u8868\u9762\u3067\u9032\u884c\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u4ea4\u63db\u53cd\u5fdc\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u76f4\u63a5\u8ffd\u8de1\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002
    \u3000CTAB \u306e\u6b8b\u5b58\u3001PSS \u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308b\u4e2d\u9593\u72b6\u614b\u3001\u305d\u3057\u3066\u6700\u7d42\u7684\u306b\u5c0e\u5165\u3055\u308c\u308b thiolated PC \u306e\u5b58\u5728\u3092\u8cea\u91cf\u30b9\u30da\u30af\u30c8\u30eb\u3068\u3057\u3066\u660e\u78ba\u306b\u691c\u51fa\u3067\u304d\u307e\u3057\u305f\u3002\u307e\u305f\u3001UV\u2013Vis\u2013NIR \u30b9\u30da\u30af\u30c8\u30eb\u3084\u30bc\u30fc\u30bf\u96fb\u4f4d\u6e2c\u5b9a\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001CTAB \u304c\u6bb5\u968e\u7684\u306b\u7f6e\u63db\u3055\u308c\u3066\u3044\u304f\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u3001\u751f\u4f53\u9069\u5408\u6027\u8868\u9762\u306e\u69cb\u7bc9\u3084\u30ca\u30ce\u7c92\u5b50\u306e\u8868\u9762\u6a5f\u80fd\u5316\u306b\u8cc7\u3059\u308b\u3001\u57fa\u76e4\u7684\u306a\u5206\u6790\u624b\u6cd5\u3068\u3057\u3066\u91cd\u8981\u306a\u4f4d\u7f6e\u3065\u3051\u3092\u6301\u3061\u307e\u3059\u3002

    Gold nanorods (AuNRs) are versatile, yet the persistent CTAB layer on their surface hinders ligand exchange. We used matrix-free LDI-TOF-MS to directly monitor this reaction on AuNR surfaces. Our analysis clearly identified residual CTAB, a PSS interaction intermediate, and the final thiolated PC. Combined with UV\u2013Vis\u2013NIR and zeta potential data, we elucidated the stepwise displacement mechanism. These findings establish a fundamental analytical approach for surface functionalization and biocompatibility.

    <\/p>\n\n\n\n

    \"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

    H.  Kawasaki*, Y.   Iwasaki, R.  ArakawaStepwise Monitoring of Ligand Exchange on Gold Nanorods: From Cetyltrimethylammonium Bromide to Thiol-Functionalized Biocompatible Phosphory Read More …<\/a><\/p>\n","protected":false},"author":61,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[18],"tags":[],"class_list":["post-3504","post","type-post","status-publish","format-standard","hentry","category-recent-publications"],"_links":{"self":[{"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/posts\/3504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/comments?post=3504"}],"version-history":[{"count":3,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/posts\/3504\/revisions"}],"predecessor-version":[{"id":3508,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/posts\/3504\/revisions\/3508"}],"wp:attachment":[{"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/media?parent=3504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/categories?post=3504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/tags?post=3504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}