{"id":673,"date":"2017-07-06T15:33:02","date_gmt":"2017-07-06T06:33:02","guid":{"rendered":"http:\/\/wps.itc.kansai-u.ac.jp\/colloid\/?page_id=673"},"modified":"2025-02-24T09:24:31","modified_gmt":"2025-02-24T00:24:31","slug":"sub03","status":"publish","type":"page","link":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/english\/sub03","title":{"rendered":"3) Functional Nanoparticles for Mass Spectrometry"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-259\" src=\"http:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/06\/reserch_zu07-300x259.png\" alt=\"\" width=\"300\" height=\"259\" srcset=\"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/06\/reserch_zu07-300x259.png 300w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/06\/reserch_zu07-768x663.png 768w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/06\/reserch_zu07-313x270.png 313w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/06\/reserch_zu07.png 786w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Matrix-assisted laser desorption\/ionization mass spectrometry (MALDI-MS) has become a workhorse technique and an indispensable tool in bioanalysis. Despite its success, it is rarely used for the analysis of small molecules (&lt;500 Da) because MALDI mass spectra suffer from high chemical background noise in the low mass region (m\/z&lt;500) due to the formation of clusters of matrix ions or matrix degradation products. Surface-assisted laser desorption\/ionization mass spectrometry (SALDI-MS) using nanomaterials (inorganic nanoparticles and nanostructured surfaces) has been reported for the LDI-MS analysis of small molecules as an organic matrix-free approach. Compared to MALDI-MS, SALDI-MS affords certain advantages, such as easy sample preparation, low background noise, high salt tolerance, and high throughput analysis for drug discovery. We have developed SALDI-MS method using functionalized nanoparticles, such as platinum-based nanomaterials, layer-by-layer (LBL) self-assembled multilayer films of gold nanoparticles, and magnetic nanoparticles, has been further improved in terms of the detection sensitivity, detection mass range from the low- to the high-mass region, a soft LDI process, the detection of both polar and nonpolar compounds, the selective detection of analytes from a complex mixture using functionalized NPs, and various applications, including imaging mass spectrometry.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-677\" src=\"http:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_ph01-1024x527.png\" alt=\"\" width=\"466\" height=\"240\" srcset=\"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_ph01-1024x527.png 1024w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_ph01-300x154.png 300w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_ph01-768x395.png 768w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_ph01-360x185.png 360w\" sizes=\"auto, (max-width: 466px) 100vw, 466px\" \/>\u3000<img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-678\" src=\"http:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_zu02-300x242.jpg\" alt=\"\" width=\"297\" height=\"240\" srcset=\"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_zu02-300x242.jpg 300w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_zu02-768x620.jpg 768w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_zu02-1024x827.jpg 1024w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_zu02-334x270.jpg 334w, https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-content\/uploads\/sites\/48\/2017\/07\/english03_zu02.jpg 1644w\" sizes=\"auto, (max-width: 297px) 100vw, 297px\" \/><\/p>\n<p>\u30fbKawasaki et al. <em>J. Phys. Chem C,<\/em> 111, 16278 (2007).<br \/>\n\u30fbKawasaki et al. <em>Anal. Chem<\/em>., 80,7524 (2008).<br \/>\n\u30fbKawasaki et al. <em>Anal. Bioanal<\/em>. Chem., 395, 1423 (2009).<br \/>\n\u30fbKawasaki et al. <em>Chemistry &#8211; A European Journal,<\/em> 16, 10832(2010).<br \/>\n\u30fbM. Inuta, et al. <em>Analyst,<\/em> 136, 1167(2011).<br \/>\n\u30fbKawasaki et al. <em>Anal. Chem<\/em>., 84, 9268 (2012).<br \/>\n\u30fbNitta et al. <em>J. Phys. Chem. C,\u00a0<\/em>117 , 238(2013).<br \/>\n\u30fbNitta et al. <em>ACS Appl. Mater. Interfaces,<\/em> 6 , 8387(2014).<br \/>\n\u30fbKurita et al. <em>Analyst,<\/em> 141, 5835 (2016).<br \/>\n\u30fbKakuta et al, <em>Mass Spectrometry,<\/em> 11, A0107 (2022).<br \/>\n\u30fbKawasaki et al., <em>Mass Spectrometry,<\/em> 13, A0162 (2024).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Matrix-assisted laser desorption\/ionization mass spectrometry (MALDI-MS) has become a workhorse technique and an indispensable tool in bioanalysis. Despite its success, it is rarely used for the analy <a href=\"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/english\/sub03\" class=\"read-more\">Read More &#8230;<\/a><\/p>\n","protected":false},"author":61,"featured_media":0,"parent":14,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-673","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/pages\/673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/comments?post=673"}],"version-history":[{"count":9,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/pages\/673\/revisions"}],"predecessor-version":[{"id":3339,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/pages\/673\/revisions\/3339"}],"up":[{"embeddable":true,"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/pages\/14"}],"wp:attachment":[{"href":"https:\/\/wps.itc.kansai-u.ac.jp\/colloid\/wp-json\/wp\/v2\/media?parent=673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}